Use a primary cell-based platform that truly represents the clinical diversity of brain cancer…
A comprehensive array of phenotypic characterizations…
• Expression microarrays mRNA and miRNA identification
• Activation states of cellular kinases and other enzymes
• Phenotypic measurements like cellular toxicity
• Real Time PCR to quantify gene expression
• FACS cell sorting to isolate cell populations of interest
• FISH analysis with specific probes
• Expression microarrays mRNA and miRNA identification
• Activation states of cellular kinases and other enzymes
• Phenotypic measurements like cellular toxicity
• Real Time PCR to quantify gene expression
• FACS cell sorting to isolate cell populations of interest
• FISH analysis with specific probes
PCR and sequencing:
IDH1, PTEN, TP53, NF1, EGFR, CDK4, INK4A-ARF, MGMT,
TIMP3, PDGFRA, 1p/19q deletion, B-Raf
Amplification by qPCR
EGFR, CDK4 and PDGFRA
Promoter methylation:
EGFR, INK4A-ARF, MGMT, TIMP3 genes
IDH1, PTEN, TP53, NF1, EGFR, CDK4, INK4A-ARF, MGMT,
TIMP3, PDGFRA, 1p/19q deletion, B-Raf
Amplification by qPCR
EGFR, CDK4 and PDGFRA
Promoter methylation:
EGFR, INK4A-ARF, MGMT, TIMP3 genes
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