Physiologically Relevant Disease Models

Objective:

• Evaluate drugs in cancer cells isolated from fresh cancer tissue to:

  • Screen new chemical or biological entities for companies
  • Generate Indian cancer patient response data by combining in vitro assays with outcomes
  • Systematically screen Indian cancers against a ‘pill box’
  • Can repurpose drugs / combinations to benefit patients
  • Conduct gene profiling of Indian cancers
  • ADVANTAGE !! mimics clinical variability in terms of:
    • Genetic diversity
    • Disease state based variations

Cancer types being cultured presently:

• Hematological
• Brain
• Breast
• Colon
• Endometrium
• Oesophagus
• Prostate
• Renal
• …

Acquisition of samples happens every day

Regulated model of Epithelial Mesenchymal Transition (EMT)

We have engineered regulated model of human EMT currently being characterized for phenotypic screens thus allowing us to perform unbiased screens!