OncoPrime

• The cells are well characterized including morphology, cell surface markers and mutation profile.
• Functional assays like migration, invasion, sphere forming assays etc. can be performed.
• We also have access to and culture adjacent non-malignant control sample where available.
• Normal healthy samples are also available from cosmetic surgeries e.g., breast, skin etc.

Cancer Hallmarks that we can target for follow-up mechanism of action studies

Saarum Sciences is well equipped with resources and equipment required for any mechanism of action (MOA) assays to be performed using these precious diseased / healthy primary cells. We can dissect mechanism of action using various technology platforms available with us.

Cancer Hallmarks**

• Sustaining proliferative signaling
• Evading growth suppressors
• Avoiding immune destruction
• Enabling replcative immortality
• Tumor promoting inflammation
• Activating invasion & metastasis
• Inducing angiogenesis
• Genome instability & mutations
• Resisting cell death
• Deregulating cellular energetics

**Adapted from Hanahan D., Weinberg R.A. Cell. 2011

Advantages of OncoPrime^TM

• Primary cell panels derived from patient samples for various tumor types*
• Short term cultures retaining clinically relevant features of the disease including heterogeneity, proliferation rate and gene expression profiles
• Provides for clinical variability
  • Genotypic diversity
  • Different disease stages spanning pre-cancerous, benign lesions to metastatic cancer
• Well characterized for driver mutations relevant to patient population
• Associated medical records of the patient for additional information